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Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients
Published on: September 9, 2020
Liquid Biopsy in Biliary Tract Cancer: When Tissue Is Not Enough
Lewis Au1,2, Jeanne Tie1,3
1Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
Abstract:
Circulating tumor DNA (ctDNA) profiling detects actionable genomic alterations in advanced biliary tract cancer faster (8 vs. 27 days) and more often (90% vs. 50%) than tissue, with high concordance. A recent retrospective study establishes clinical validity and a compelling access case for future prospective ctDNA-directed trials. See related article by Visa et al., p. 4374.
