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Updated: Aug 5, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
Celiac disease incidence after COVID-19 infection
Christina Mastori-Kourmpani1, Theodosios D Filippatos2, Aris P Agouridis1
1Second Department of Internal Medicine, Hippokration University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Background:
An increased incidence of auto-inflammatory diseases, such as celiac disease (CD), has been reported following coronavirus disease 2019 (COVID-19) pandemic. The aim of this systematic review and meta-analysis was to assess whether COVID-19 is associated with CD risk.
Methods:
We searched MEDLINE (PubMed), Cochrane Library and Clinicaltrial.gov databases up to October 30, 2025, for studies evaluating the incidence of CD following COVID-19 infection (PROSPERO ID: CRD420251174742). We performed qualitative and quantitative syntheses of retrospective studies to evaluate the role of COVID-19 infection in CD incidence.
Results:
A total of 4 studies were used in the qualitative and quantitative analysis. The studies were conducted between 2023 and 2024 and included 3,465,996 exposed and 7,044,493 non-exposed COVID-19 people. The results from the pooled synthesis showed no significant difference in CD incidence among exposed and non-exposed people with COVID-19 (risk ratio [RR] 1.25, 95% confidence interval [CI; 0.94, 1.66], P=0.12, I2=87%). Similarly, no difference was observed in CD incidence between COVID-19 and non-COVID-19 patients after performing a leave-one-out sensitivity analysis (RR 1.10 95% CI [1.00, 1.22], P=0.06, I2=0%).
Conclusions:
These findings suggest that COVID-19 infection does not appear to increase the risk of developing CD.
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