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[Clinical practice guidelines "Congenital adrenal hyperplasia in children" with comments]

I S Chugunov1, I V Kopylova1, A A Kolodkina1

  • 1Endocrinology Research Centre.

Problemy Endokrinologii
|August 3, 2026
PubMed

Insights

This summary provides updated clinical practice guidelines for congenital adrenal hyperplasia (CAH) in children, covering diagnosis, treatment, and follow-up based on current research.

Area of Science:

  • Pediatric Endocrinology
  • Genetics
  • Metabolic Disorders

Background:

  • Congenital adrenal hyperplasia (CAH) encompasses a group of genetic disorders affecting the adrenal glands.
  • Accurate diagnosis and management are crucial for preventing severe health complications in children.
  • Existing guidelines require updates to reflect current scientific understanding and clinical evidence.

Purpose of the Study:

  • To present comprehensive clinical practice guidelines for congenital adrenal hyperplasia (CAH) in children.
  • To systematically outline epidemiology, etiology, pathogenesis, and diagnostic methods for all CAH forms.
  • To provide updated protocols for hormone replacement therapy and patient follow-up.

Main Methods:

  • Development and approval by pediatric endocrinologists from the Russian Association of Endocrinologists.
  • Endorsement by the Russian Federation Ministry of Health council.
  • Inclusion of systematic reviews, meta-analyses, original articles, and international studies on CAH.

Main Results:

  • Guidelines systematically cover CAH epidemiology, etiology, pathogenesis, and diagnostics.
  • Protocols for glucocorticoid and mineralocorticoid replacement therapy are detailed.
  • Age-specific follow-up regimens for pediatric CAH patients are provided.

Conclusions:

  • These guidelines offer a systematic approach to diagnosing and managing CAH in children.
  • Updated author comments clarify critical aspects of CAH diagnosis and treatment.
  • The guidelines serve as a vital resource for pediatric endocrinologists and healthcare providers.

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