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Updated: Aug 5, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Published on: March 7, 2019
Diverging Clinical and Amyloid Positron Emission Tomography Features in Iatrogenic Cerebral Amyloid Angiopathy
Nobuo Sanjo1,2,3, Ryoko Muramatsu1, Kota Yokoyama4
1Department of Neurology and Neurological Science, Institute of Science Tokyo, Graduate School of Medical and Dental Sciences, Tokyo, Japan.
Abstract:
Amyloid positron emission tomography (PET) features of cadaveric dural graft-associated iatrogenic cerebral amyloid angiopathy (iCAA) remain unclear. A 53-year-old man presented with forgetfulness and personality changes 41 years postgrafting. Cognitive test results revealed memory impairments; magnetic resonance imaging revealed medial temporal lobe atrophy, multiple microbleeds, and superficial siderosis; and amyloid PET revealed focal occipital uptake. Although focal amyloid accumulation associated with cognitive impairment has not been reported in patients with iCAA, decreased cerebrospinal fluid levels of amyloid-β 40 and 42, with normal levels of amyloid-β 42/40 ratio, p-tau 181, and total tau levels, suggest that iCAA may be a major underlying pathology.
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