Diverging Clinical and Amyloid Positron Emission Tomography Features in Iatrogenic Cerebral Amyloid Angiopathy
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Updated: Aug 5, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Published on: March 7, 2019
Nobuo Sanjo1,2,3, Ryoko Muramatsu1, Kota Yokoyama4
1Department of Neurology and Neurological Science, Institute of Science Tokyo, Graduate School of Medical and Dental Sciences, Tokyo, Japan.
Abstract:
Amyloid positron emission tomography (PET) features of cadaveric dural graft-associated iatrogenic cerebral amyloid angiopathy (iCAA) remain unclear. A 53-year-old man presented with forgetfulness and personality changes 41 years postgrafting. Cognitive test results revealed memory impairments; magnetic resonance imaging revealed medial temporal lobe atrophy, multiple microbleeds, and superficial siderosis; and amyloid PET revealed focal occipital uptake. Although focal amyloid accumulation associated with cognitive impairment has not been reported in patients with iCAA, decreased cerebrospinal fluid levels of amyloid-β 40 and 42, with normal levels of amyloid-β 42/40 ratio, p-tau 181, and total tau levels, suggest that iCAA may be a major underlying pathology.
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