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Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow
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Salt-induced matrix effects on PFAS quantification in online SPE-LC-MS/MS analysis

Aleum Lee1, Soo Min Song1,2, Hee Sun Moon3,4

  • 1Groundwater Environment Research Center, Geo-Environment Research Division, Korea Institute of Geoscience and Mineral Resources (KIGAM), Daejeon, 34132, Korea.

Analytical and Bioanalytical Chemistry
|August 3, 2026
PubMed
Summary

Residual inorganic ions in water significantly impact perfluoroalkyl substances (PFAS) quantification using online SPE-LC-MS/MS. Salt addition improves detection limits for short-chain PFAS but complicates accurate measurement due to incomplete internal standard correction.

Keywords:
ExtractionMatrix effectsOnline SPE-LC–MS/MSPer- and polyfluoroalkyl substances (PFAS)Quality assurance/control

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