Cardiovascular Care in Multiple Myeloma: A Comprehensive Review and Integrated Systems-Based Approach from a UK

Daniel Akrawi1,2,3, Shayan Datta1, Suzan Hatipoglu1,4

  • 1Cardio-Oncology Service, University College London Hospital, University College London Hospitals NHS Foundation Trust, London, UK.

Insights

Managing cardiovascular risks in multiple myeloma is crucial. Integrated cardio-oncology services improve patient outcomes by monitoring and managing treatment-related heart issues throughout the patient journey.

Area of Science:

  • Cardio-oncology
  • Hematology
  • Cardiovascular Medicine

Background:

  • Multiple myeloma (MM) patients face significant cardiovascular risks.
  • These risks stem from disease factors like cardiac amyloidosis and treatment cardiotoxicity.

Purpose of the Study:

  • To review cardiovascular complications in multiple myeloma and its therapies.
  • To emphasize integrated cardiovascular management and the University College London Hospital Cardio-Oncology Centre model.

Main Methods:

  • Longitudinal risk stratification before, during, and after anti-myeloma therapy.
  • Multidimensional assessment including patient, disease, and treatment factors.
  • Active surveillance with clinical assessment, biomarkers, and imaging.

Main Results:

  • Cardiovascular vulnerability is multifactorial in MM.
  • Integrated cardio-oncology services improve management and outcomes.
  • Early referral and intervention are key for high-risk patients.

Conclusions:

  • Integrated cardio-oncology services are vital for preserving cardiovascular health in MM patients.
  • A systems-based approach ensures timely intervention and survivorship care.
  • Multidisciplinary collaboration enhances patient management and access to effective therapies.
Abstract

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