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Updated: Aug 5, 2026
08:53
Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
Classic Hodgkin Lymphoma: A Review
Kishan K Patel1, Alison J Moskowitz1
1Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, New York.
JAMA
|August 3, 2026
Summary
Classic Hodgkin lymphoma (cHL) is a B-cell malignancy with high cure rates up to 90%. Treatment involves chemotherapy, with novel agents and stem cell transplant for advanced or refractory cases, but survivors face risks of secondary conditions.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Hodgkin lymphoma (HL) is a B-cell lymphoid malignancy with significant global incidence and mortality.
- Classic HL (cHL) comprises 90-95% of cases, presenting with a bimodal age distribution and often supradiaphragmatic lymphadenopathy.
- Risk factors include Epstein-Barr virus, immune dysregulation, and familial predisposition.
Purpose of the Study:
- To outline the epidemiological characteristics, risk stratification, and evolving treatment paradigms for classic Hodgkin lymphoma.
- To highlight the efficacy of current therapies and the long-term sequelae in survivors.
Main Methods:
- Review of epidemiological data and clinical presentation of cHL.
- Analysis of risk stratification factors for early-stage disease.
- Summary of current and novel therapeutic strategies, including chemotherapy, immunotherapy, and stem cell transplantation.
Main Results:
- cHL exhibits a bimodal age distribution with a median diagnosis age of 33 years.
- Risk stratification incorporates age, B symptoms, disease bulk, nodal sites, and extranodal involvement.
- High cure rates (up to 90%) are achievable with current treatments, including chemotherapy, radiotherapy, novel agents, and stem cell transplant.
Conclusions:
- First-line treatment for cHL combines chemotherapy with radiotherapy for early-stage disease, and novel agents for advanced or unfavorable early-stage cases.
- Stem cell transplant is crucial for relapsed or refractory cHL.
- Survivors of cHL face increased risks of secondary malignancies and organ dysfunction, necessitating long-term monitoring.
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