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Associations Between Multiple Chemosensory Dysfunction and Cognition
Michelle Yu1, Stephanie M Horton1, Tiffany Chen2
1Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
International Forum of Allergy & Rhinology
|August 3, 2026
Summary
Cognitive function may be linked to chemosensory dysfunction. This study found a connection between trigeminal nerve dysfunction and cognitive abilities, using a new thermoprobe assessment method.
Area of Science:
- Neuroscience
- Sensory Science
- Cognitive Psychology
Background:
- Chemosensory dysfunction, including smell and taste impairments, is increasingly recognized for its potential impact on overall health.
- The trigeminal nerve plays a crucial role in sensing touch, temperature, and pain in the face, and its function may influence cognitive processes.
- Existing methods for assessing trigeminal nerve function are limited, hindering research into its relationship with cognition.
Purpose of the Study:
- To investigate the association between chemosensory dysfunction and cognitive performance.
- To introduce and validate novel methods for assessing trigeminal nerve function using the Medoc TSA-II thermoprobe.
- To determine if subjective trigeminal dysfunction correlates with cognitive status.
Main Methods:
- Utilized the Medoc TSA-II thermoprobe to quantitatively assess trigeminal nerve sensory function, specifically thermal detection thresholds.
- Collected subjective reports of trigeminal dysfunction from participants.
- Administered standardized cognitive tests to evaluate various cognitive domains.
Main Results:
- A significant association was found between subjective trigeminal dysfunction and impaired cognitive performance.
- The study successfully demonstrated the utility of the Medoc TSA-II thermoprobe for assessing trigeminal function in a research setting.
- Preliminary findings suggest a link between trigeminal sensory deficits and cognitive decline.
Conclusions:
- This research supports a link between impaired chemosensory (trigeminal) function and cognitive deficits.
- The Medoc TSA-II thermoprobe offers a valuable tool for investigating trigeminal nerve involvement in neurological and cognitive conditions.
- Subjective reports of trigeminal dysfunction are indicative of underlying cognitive changes.
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