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Updated: Aug 5, 2026
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A Translational Surgical Porcine Model for Postoperative Intra-Abdominal Adhesion Formation
Published on: March 13, 2026
Selective Non-Operative Management After Abdominal Gunshot and Blast Injuries in A Porcine Model
Xiaohan Liu1, Chun Ye2, He Zhang3
1Military Medical Research Group, Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Dalian Medical University); Graduate School, Dalian Medical University.
Journal of Visualized Experiments : Jove
|August 3, 2026
Summary
Selective non-operative management (SNOM) was explored in new animal models for gunshot and blast injuries. While successful in some cases, SNOM requires careful monitoring due to potential failure requiring surgery or leading to death.
Area of Science:
- Trauma Surgery
- Surgical Innovation
- Animal Models in Research
Background:
- Selective non-operative management (SNOM) is gaining recognition for trauma but lacks animal model validation.
- Gunshot and blast injuries present unique challenges in trauma care.
Purpose of the Study:
- To establish and evaluate preliminary porcine models for gunshot and blast injuries.
- To compare the outcomes of SNOM versus immediate laparotomy in these models.
Main Methods:
- 24 male pigs were divided into gunshot (12) and blast (12) injury models.
- Animals were randomized to immediate surgery or SNOM groups.
- SNOM involved Focused Assessment with Sonography for Trauma (FAST) and criteria for surgical conversion.
Main Results:
- Gunshot model: 7-day survival was 91.67%. SNOM had 1 conversion, 1 death, and 4 successes.
- Blast model: 7-day survival was 100%. SNOM had 2 conversions and 4 successes.
- Immediate surgery groups showed varying rates of therapeutic and negative laparotomies.
Conclusions:
- Preliminary porcine models for gunshot and blast injuries were successfully established.
- SNOM is a viable strategy in these models but necessitates vigilant monitoring.
- Further research is needed to refine SNOM protocols for complex trauma.
