MedHallTune: An Instruction-Tuning Benchmark for Mitigating Medical Hallucination in Vision-Language Models

The increasing use of vision-language models (VLMs) in healthcare applications presents great challenges related to hallucinations, in which the models may generate seemingly plausible results that are in fact incorrect. Such hallucinations can jeopardize clinical decision making, potentially harming the diagnosis and treatments. In this work, we propose MedHallTune, a large-scale benchmark designed specifically to evaluate and mitigate hallucinations in medical VLMs. Comprising over 100,000 images and 1,000,000 instruction pairs, MedHallTune includes both hallucination and non-hallucination samples. While the dataset is primarily constructed using GPT-based generation and filtering, the evaluation split is manually verified by medical students and physicians to ensure annotation correctness and clinical reliability. We conduct a comprehensive evaluation of current medical and general VLMs using MedHallTune, assessing their performance across key metrics, including clinical accuracy, relevance, detail level, and risk level. The experimental results show that fine-tuning with MedHallTune successfully improves the ability of several existing models to manage hallucinations and boost their zero-shot performance on downstream visual-question-answering tasks, making them more reliable for practical medical applications. Our work contributes to the development of more trustworthy VLMs. The benchmark, evaluation codes and data construction prompts will be made publicly available at MedHallTune.