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Precise Control of the Release Behavior of Multiphase Delivery Systems and Their Innovative Applications in
Nianjie Feng1, Xin Liu2, Xiaotian Zhu2
1Hubei University of Technology, Hubei University of Technology, Wuhan, 430068, China.
Biomedical Physics & Engineering Express
|August 3, 2026
Summary
Multiphase delivery systems offer advanced drug loading and release control. This review examines their preparation, mechanisms, and applications in human, animal, and plant medicine, highlighting current challenges.
Area of Science:
- Biomedical Engineering
- Materials Science
- Drug Delivery
Background:
- Multiphase delivery systems, comprising two or more components, are recognized for their significant drug loading capacity and controlled release capabilities.
- These systems enable precise drug release modulation through adjustments in structural and interfacial properties, attracting considerable research interest in biomedicine.
Purpose of the Study:
- To systematically review multiphase delivery systems, focusing on their transformation processes, formation mechanisms, and influencing factors.
- To examine the applications of these systems in human medicine and compare their use in animal and plant medicine.
- To provide a comprehensive overview of the current status and challenges associated with multiphase delivery systems.
Main Methods:
- Systematic literature review of multiphase delivery systems.
- Analysis of formation mechanisms and influencing factors.
- Comparative study of applications across human, animal, and plant medicine.
Main Results:
- Multiphase systems demonstrate high drug loading and release regulation but face challenges in stability, release prediction, and preparation complexity.
- Detailed examination of transformation processes based on formation mechanisms and influencing factors for diverse systems.
- Exploration of applications in human, animal, and plant medicine, with comparative insights.
Conclusions:
- Multiphase delivery systems hold significant potential in drug delivery, but overcoming current limitations is crucial for broader application and industrialization.
- Understanding formation mechanisms and influencing factors is key to optimizing system design and performance.
- Comparative analysis reveals potential for cross-disciplinary advancements in medicine and agriculture.
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