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Antidepressant Use and Withdrawal: A Review of Current Evidence and Clinical Recommendations
David Cohen1, Camila Losada Strassle2, Nicolas Badre3
1Department of Social Welfare, Luskin School of Public Affairs, University of California, Los Angeles, Los Angeles, CA, USA.
Abstract:
Long-term use of antidepressants increased along with viewing depression as a chronic relapsing condition. Treatment guidelines-citing clinical trials with persistent flaws that may lead to conflation of relapse with antidepressant withdrawal syndromes-recommended continued medication after remission to reduce relapse, and offered inadequate information on safely tapering patients off medication. Withdrawal is increasingly discussed in the literature and by lay users addressing sparse discontinuation guidance. Research is critically lacking that tests hypotheses of drug-induced iatrogenesis like post-withdrawal disorders. The uncertain state of the current evidence base should inform how providers communicate with patients about withdrawal syndromes.
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