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Management of Heyde syndrome with argon plasma coagulation and transcatheter aortic valve implantation

Martin Gomez1, Alejandro Concha2,3, Andres Ruano2

  • 1Director of Gastroenterology Unit, Internal Medicine Department, Universidad Nacional de Colombia, Bogotá, Colombia magomezz@unal.edu.co.

BMJ Case Reports
|August 3, 2026
PubMed

Heyde syndrome (HS) is defined as the association between severe aortic valve stenosis and angiodysplasias (AD)-related bleeding. It is thought to occur as a consequence of an acquired type 2A von Willebrand disease, promoted by the high shear stress generated by the stenotic valve. It appears to be an underdiagnosed condition. We report a case of HS in which gastrointestinal (GI) bleeding was identified in duodenal and jejunal AD. Bleeding was successfully treated with argon plasma coagulation. Additionally, the patient underwent a transcatheter aortic valve implantation, after which he experienced improvement in heart failure symptoms and no further episodes of GI bleeding.

Keywords:
EndoscopyGI bleedingInterventional cardiologySmall intestine

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