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Crystallization Inhibition and Solid-State Stability in High Drug Loaded Amorphous Drug-Polymer Dispersions Above the

Sichen Song1,2, Ronald A Siegel3,4

  • 1Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, 55455, USA.

Pharmaceutical Research
|August 3, 2026
PubMed
Summary

Amorphous solid dispersions (ASDs) improve drug solubility. Polymer concentration relative to overlap concentration (c*) dictates drug crystallization, with higher concentrations preventing it for better oral bioavailability.

Keywords:
amorphous solid dispersioncrystal growthcrystallizationnucleationoverlap concentrationsolid state stabilityviscosity

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