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Emerging agents and regimens for myeloproliferative neoplasms: updates from ASH 2025 Annual Meeting

Tiantian Zhang1,2, Heng Jiang3, Delong Liu4,5

  • 1Department of Internal Medicine, University of Central Florida, Pensacola, FL, 32514, USA.

Experimental Hematology & Oncology
|August 4, 2026
PubMed

Insights

New myeloproliferative neoplasm (MPN) therapies are emerging to overcome current treatment limits. Investigational agents targeting MPN clones, sparing phlebotomy, and modifying disease offer potential for improved outcomes.

Area of Science:

  • Hematology
  • Oncology
  • Molecular Medicine

Background:

  • Current myeloproliferative neoplasm (MPN) treatments offer symptom control but have limitations.
  • These include infrequent molecular remissions and treatment-limiting cytopenias, particularly anemia.
  • Existing therapies often rely on non-mutation-directed cytoreduction or phlebotomy, causing morbidity.
Keywords:
CALRINCA033989JAK2Myeloproliferative neoplasmPelabresibRusfertide

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