Spatially resolved transcriptomic profiling of myelofibrosis spleen reveals compartment specific niche programs
Edoardo Peroni1, Marco Pizzi2, Marco Basso3
1Immunology and Molecular Oncology Unit, Veneto Institute of Oncology, IOV-IRCCS, Padova, 35128, Italy. edoardo.peroni@iov.veneto.it.
Experimental Hematology & Oncology
|August 4, 2026
Summary
Myelofibrosis splenomegaly involves distinct splenic niches. Spatial transcriptomics reveals specialized functions in intravascular, perivascular, and red pulp compartments, highlighting microenvironmental dependencies.
Area of Science:
- Hematology
- Cancer Biology
- Genomics
Background:
- Myelofibrosis (MF) causes splenomegaly due to extramedullary hematopoiesis (EMH) and splenic microenvironment alterations.
- The spleen in MF exhibits compartmental organization into distinct niches, influencing disease pathology.
