Green synthesis of phenol/indole-substituted dihydroisoquinoline derivatives under catalyst-free conditions
Ziqiang Meng1, Linlin Zhao1, Lekang Fu1
1School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan, 411201 China. zhao_yunhui@163.com.
Abstract:
A catalyst-free and efficient protocol for the synthesis of phenol/indole-substituted dihydroisoquinolines has been developed using DMSO as the solvent, affording the target products in moderate to good yields. This method features a broad substrate scope and demonstrates gram-scale synthetic potential. Biological evaluation revealed that several compounds exhibit promising antitumor and antibacterial activities; notably, compound 4o exhibits an IC50 value of 15.20 µM against MDA-MB-231 cells, outperforming the positive control.
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