Related Experiment Video
Updated: Aug 5, 2026

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
Published on: March 1, 2022
Tracheobronchial Wall Thickening in a Patient With Inflammatory Bowel Disease
Jonathan Tse1, Kevyn Ramos Laguna1, Shuman Liu2
1Department of Internal Medicine, Keck School of Medicine of USC, Los Angeles, CA.
Abstract:
A 43-year-old woman, born in Mexico, with a history of idiopathic thrombocytopenic purpura status after splenectomy and inflammatory bowel disease (IBD) favoring Crohn disease previously complicated by cytomegalovirus (CMV) colitis, presented with worsening abdominal and rectal pain. Over the past 6 months, she had 3 hospitalizations for biopsy-confirmed IBD flares, during which her immunosuppressive regimen was sequentially intensified from azathioprine and infliximab to high-dose corticosteroids and ultimately to upadacitinib for refractory disease.
Related Concept Videos
Inflammatory Bowel Disease III: Crohn's Disease
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Inflammatory Bowel Disease II: Ulcerative Colitis
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
