Microbiotherapy: an emerging adjunct for burn wound healing
Junxiao Zhang1, Kangrui Zhang1, Yiran Wang1
1School of Pharmacy, Shandong Second Medical University, Weifang, Shandong, China.
Frontiers in Cellular and Infection Microbiology
|August 4, 2026
Summary
Microbiotherapy offers a promising alternative for burn wound management by combating antibiotic resistance and enhancing healing. This approach utilizes probiotics, bacteriophages, and microbial derivatives to restore immune balance and promote tissue repair.
Area of Science:
- Regenerative Medicine
- Microbiology
- Wound Healing
Background:
- Burn injuries cause significant skin trauma, with traditional antibiotic treatments facing challenges like drug resistance and limited efficacy.
- Novel therapeutic strategies are crucial for effective burn wound management.
Purpose of the Study:
- To review recent advancements in microbiotherapy for burn wound treatment.
- To explore the mechanisms of action, in vivo studies, and combined applications of microbiotherapies.
- To critically evaluate the future opportunities and translational challenges of microbiotherapy in clinical settings.
Main Methods:
- Literature review summarizing current research on microbiotherapy for burn wounds.
- Analysis of mechanisms including competitive inhibition, metabolite secretion, and immune modulation.
- Evaluation of studies involving probiotics, bacteriophages, and microbial metabolic derivatives.
Main Results:
- Microbiotherapy demonstrates antibacterial effects and promotes burn wound healing through anti-inflammatory and growth factor secretion.
- Restoration of immune homeostasis is a key benefit of microbial interventions.
- Probiotics, bacteriophages, and microbial metabolic derivatives are key components, showing potential for combined use.
Conclusions:
- Microbiotherapy presents a viable, personalized approach to burn wound management, moving from research to clinical application.
- Further research is needed to overcome translational challenges and fully realize the clinical potential of these microbial therapies.
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