Linear dose-response relationship between TyG-WC index and diastolic dysfunction: insights from restricted cubic
Yanbo Xia1, Jin Wang1, Zhiwei Huang1
1Luohe Central Hospital, Luohe Medical College, Luohe, China.
Frontiers in Endocrinology
|August 4, 2026
Summary
The triglyceride-glucose waist circumference (TyG-WC) index is linked to a higher risk of diastolic dysfunction (DD) in middle-aged and older adults. This accessible marker can aid in early heart failure screening.
Area of Science:
- Cardiology
- Metabolic Syndrome
- Heart Failure Research
Background:
- Diastolic dysfunction (DD) is a key precursor to heart failure, often associated with metabolic stress.
- The relationship between the triglyceride-glucose waist circumference (TyG-WC) index and DD needs further clarification using current diagnostic criteria.
Purpose of the Study:
- To investigate the association between the TyG-WC index and the risk of developing DD.
- To evaluate TyG-WC as a potential screening tool for subclinical heart failure in a community-based population.
Main Methods:
- A cross-sectional study involving 1,413 middle-aged and older adults.
- DD diagnosis based on age-stratified echocardiographic criteria.
- Analysis using multivariable logistic regression, restricted cubic splines (RCS), and machine learning (LASSO, Random Forest, SHAP).
Main Results:
- Elevated TyG-WC showed an independent association with increased DD risk (OR = 1.002).
- High TyG-WC group had a significantly higher risk of DD (OR = 1.656).
- A linear dose-response relationship was observed between TyG-WC and DD probability; machine learning confirmed TyG-WC's predictive contribution.
Conclusions:
- The triglyceride-glucose waist circumference (TyG-WC) index is independently associated with an elevated risk of diastolic dysfunction.
- TyG-WC serves as a practical, cost-effective marker for cardiometabolic stress, useful for early subclinical heart failure detection and risk stratification.
