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Updated: Aug 5, 2026

Intravascular Delivery of Biologics to the Rat Kidney
Published on: September 1, 2016
Evaluation of renal function in a patient with terminal rectal cancer who developed morphine hydrochloride-induced
Yoshihiro Uekuzu1,2, Masanobu Usui2, Akihiko Futamura2,3
1Department of Pharmacy, Fujita Health University Okazaki Medical Center, Okazaki, Aichi, Japan.
Abstract:
A challenge in patients with terminal cancer is that serum creatinine-based estimates of renal function often deviate from true renal function because cachexia-related loss of muscle mass leads to abnormally low serum creatinine levels. Serum cystatin C is a useful marker of renal function in patients with decreased muscle mass; however, there are limited data on its use in patients with terminal cancer. In this study, we present a detailed assessment of renal function, incorporating muscle mass measurement by bioelectrical impedance analysis, in a patient with terminal rectal cancer who developed respiratory depression while receiving a stable dose of morphine hydrochloride injections.
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