A Rare Balanced Translocation between Chromosome 1 and 10 in a Female with a History of Recurrent Pregnancy Loss: A...

Recurrent pregnancy loss (RPL) is defined as two or more failed clinical pregnancies, involuntarily ending before 24 weeks of gestation. Approximately 2%-5% of couples with recurrent miscarriages carry a balanced structural chromosomal anomaly. A non-consanguineous couple with a history of RPL was referred to the institute for genetic evaluation. The male and the female partners were of ages 31 and 30 years, respectively. The reproductive history of the female partner revealed three missed abortions during the 8^th-10^th week of pregnancy. The karyotype of the female partner revealed balanced chromosomal translocation between the long arm of chromosome 1 and the short arm of chromosome 10 (46, XX, t(1;10)(q32;p14)) with a clinically normal phenotype. The male partner had a normal karyotype (46, XY).