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Updated: Aug 5, 2026

Quantitative Polymerase Chain Reaction (qPCR)-Based Rapid Diagnosis of Helicobacter pylori Infection and Antibiotic Resistance
Published on: July 28, 2023
Atypical acute Helicobacter pylori infection without atrophic gastritis: A case report
Ryuzo Deguchi1, Haruhiko Ogata1
1Department of Gastroenterology, Fujita Health University Haneda Clinic, Ota, Tokyo, Japan.
Abstract:
A 64-year-old Chinese man visited our clinic's health-screening center. The patient tested negative for Helicobacter pylori (HP) infection in his home country, but at this visit, anti-HP antibodies of 5 U/mL and a urea breath test (UBT) result of 48.6‰ were detected. Upper gastrointestinal endoscopy showed no atrophic gastritis, and a regular arrangement of collecting venules was observed. Since a false-positive UBT was also considered, Smart Gene testing was performed, which confirmed the HP positivity. As no clarithromycin resistance mutation was detected, Japan's first-line eradication regimen was prescribed. The eradication test result was a UBT of 0.1‰, confirming successful HP eradication.
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