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PDGFD-Rearranged Dermatofibrosarcoma Protuberans With S100 and Pan-TRK Expression
Venezia Podesta1, May P Chan2,3, Douglas Rottmann2
1University of Michigan, Ann Arbor, Michigan, USA.
Journal of Cutaneous Pathology
|August 4, 2026
Summary
Dermatofibrosarcoma protuberans (DFSP) can rarely involve PDGFD rearrangements, not just PDGFB. This case highlights the importance of considering DFSP in spindle cell tumors, even with initial atypical molecular findings.
Area of Science:
- Oncology
- Dermatopathology
- Molecular Pathology
Background:
- Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer.
- Most DFSP cases involve COL1A1::PDGFB gene fusions.
- Alternative rearrangements, including PDGFD, are less common.