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Primary Hyperparathyroidism-Induced Acute Pancreatitis: Case Report and Systematic Review
Fei Che1, Dongfeng Lv, YaDong Liu
1Department of Emergency, Xi'an No. 3 Hospital, Xi'an, Shaanxi, China.
Pancreas
|August 4, 2026
Summary
Primary hyperparathyroidism (PHPT) can cause acute pancreatitis (AP). Early diagnosis and parathyroidectomy (PTX) are crucial for treating PHPT-associated AP and preventing recurrence.
Area of Science:
- Endocrinology
- Gastroenterology
- Surgical Oncology
Background:
- Primary hyperparathyroidism (PHPT) is a rare metabolic disorder.
- PHPT can manifest as acute pancreatitis (AP), necessitating timely diagnosis and intervention.
Purpose of the Study:
- To investigate the clinical presentation and management of PHPT-associated AP.
- To evaluate the efficacy of parathyroidectomy (PTX) in resolving AP and preventing recurrence.
Main Methods:
- Retrospective analysis of a patient with AP and severe hypercalcemia due to PHPT.
- Systematic review of 83 studies (107 patients) on PHPT-associated AP, adhering to PRISMA guidelines.
Main Results:
- The index patient presented with AP and severe hypercalcemia (3.54 mmol/L), successfully treated with PTX.
- Systematic review revealed a median age of 38 years, 41.1% male patients, and median peak calcium of 3.25 mmol/L.
- PTX was performed in 88.8% of PHPT-AP patients, with no reported recurrence in 75% of survivors with follow-up data.
Conclusions:
- PHPT is a treatable cause of AP, warranting consideration in idiopathic or recurrent cases.
- Routine screening for calcium and parathyroid hormone (PTH) is recommended for AP.
- Early PTX is safe and curative for PHPT-AP, with timing adjusted based on hypercalcemia severity.
Keywords:
acute pancreatitishypercalcemiaparathyroidectomyprimary hyperparathyroidismsystematic reviewMore Related Videos
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