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Lesions Reported as Plaque-Like CD34-Positive Dermal Fibroma Reveal Two Reproducible Clinicopathologic Patterns: Two
Wei Tan1, Mingyuan Xu1, Yeqiang Liu1
1Department of Pathology, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Journal of Cutaneous Pathology
|August 4, 2026
Summary
Plaque-like CD34-positive dermal fibroma (PDF) and medallion-like dermal dendrocyte hamartoma (MDDH) lesions may represent two distinct clinicopathologic patterns. Recognizing these patterns aids in differentiating them from other CD34-positive spindle-cell tumors.
Area of Science:
- Dermatopathology
- Oncology
- Histopathology
Background:
- Plaque-like CD34-positive dermal fibroma (PDF) and medallion-like dermal dendrocyte hamartoma (MDDH) are rare, benign spindle-cell lesions.
- Existing clinicopathologic descriptions are highly variable, leading to diagnostic challenges.
