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Are children with isolated renal ectopia at increased risk of hypertension? Evidence from an observational study

Gorkem Sahin1, Cagla Cagli Piskin2, Zahide Orhan Ok1

  • 1Department of Pediatric Nephrology, Faculty of Medicine, Çukurova University, Adana, Türkiye.

Journal of Nephrology
|August 4, 2026
PubMed

Insights

Children with isolated renal ectopia have high rates of masked hypertension and abnormal nocturnal blood pressure patterns. Regular monitoring of growth, kidney function, and blood pressure is crucial for early detection of complications.

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Health in Children
  • Renal Imaging and Function

Background:

  • Isolated renal ectopia is a congenital anomaly that may affect blood pressure.
  • Understanding blood pressure profiles in these children is crucial for management.

Purpose of the Study:

  • To evaluate blood pressure (BP) profiles in children with isolated renal ectopia using ambulatory blood pressure monitoring (ABPM).
  • To determine the prevalence and patterns of hypertension.
  • To explore relationships between ectopy subtype and kidney function.

Main Methods:

  • Retrospective evaluation of clinical and ABPM data from 24 children with isolated renal ectopia.
  • Assessment of ectopy type, renal parenchymal uptake (DMSA), estimated glomerular filtration rate (eGFR), and end-organ damage.
  • Recording of anthropometric measurements and office/24-hour BP values using standard deviation scores (SDS).

Main Results:

  • Masked hypertension was identified in 45.8% of patients.
  • Lower eGFR correlated with higher 24-hour systolic BP SDS and nighttime BP SDS.
  • Decreased renal parenchymal uptake was associated with lower height SDS, higher nighttime systolic BP SDS, and increased systolic non-dipping.
  • Crossed-fused ectopia showed higher rates of vesicoureteral reflux and lower eGFR.

Conclusions:

  • Children with isolated renal ectopia exhibit a high prevalence of ABPM abnormalities, including masked hypertension and altered nocturnal BP patterns.
  • Regular monitoring of growth, kidney function, and BP is essential for detecting early and late complications.
Abstract

Keywords:
Renal ectopiacrossed-fused renal ectopiahypertensionvesicoureteral reflux

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