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The Effect of Midurethral Slings on Overactive Bladder Medication Use in Women with Mixed Urinary Incontinence
Amina Igeh1, Emir Gurbuz2, Savci B Telek2
1Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Urogynecology and Reconstructive Pelvic Surgery, Yale School of Medicine, New Haven, CT, USA. amina.igeh@yale.edu.
International Urogynecology Journal
|August 4, 2026
Summary
Midurethral sling (MUS) placement for mixed urinary incontinence (MUI) shows varied effects on overactive bladder (OAB) medication needs. While many patients remain stable, some initiate, escalate, or discontinue OAB treatments post-surgery.
Area of Science:
- Urology
- Gynecology
- Pelvic Health
Background:
- Mixed urinary incontinence (MUI) impacts quality of life, combining stress and urgency symptoms.
- Midurethral sling (MUS) procedures are used for SUI, with potential benefits for urgency symptoms.
Purpose of the Study:
- To evaluate changes in the need for overactive bladder (OAB) medications after midurethral sling (MUS) placement in women with MUI.
- To analyze postoperative OAB treatment trajectories, including initiation, continuation, escalation, and discontinuation.
Main Methods:
- Retrospective cohort study of 617 women with MUI undergoing MUS placement (2017-2023).
- Patients stratified by preoperative OAB medication use.
- Follow-up of at least 6 months to assess OAB treatment changes.
Main Results:
- Among 115 women on OAB medications preoperatively, 25.2% discontinued therapy, 62.6% continued, and 12.2% escalated.
- Of 502 women not on OAB medications preoperatively, 14.7% initiated therapy postoperatively.
- Younger age was associated with initiating OAB therapy post-MUS.
Conclusions:
- Postoperative OAB treatment needs following MUS placement for MUI are heterogeneous.
- A significant subset of patients require adjustments in OAB pharmacotherapy after surgery.
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