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Updated: Aug 5, 2026

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Published on: October 30, 2016

The CREM-IL-15 axis: decoding the persistence-exhaustion paradox in NK cell immunotherapy

Amr Ali Mohamed Abdelgawwad El-Sehrawy1, Mutaz Jamal Al-Khreisat2, Jalpa R Patel3

  • 1Internal Medicine, Diabetes, Endocrinology and Metabolism, Mansoura University, Mansoura, Egypt. Elsehrawyamralimohamedabdelgaw@gmail.com.

Cancer Immunology, Immunotherapy : CII
|August 4, 2026
PubMed
Summary

The CREM-IL-15 signaling axis regulates natural killer (NK) cell activity. Understanding this axis is key to improving NK cell immunotherapy by balancing persistence and preventing exhaustion for better cancer treatment.

Keywords:
CREMCancerCytokineIL-15ImmunotherapyNK cell

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