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Association Between Systemic Inflammation Response Index and All-Cause Mortality in Individuals with Chronic Pain:
Liang-Wen Li1,2, Chen-Yu Zhu1, Yunjie Chen1
1Department of Pain Management, West China Hospital, Sichuan University, Chengdu, China.
Pain Physician
|August 4, 2026
Summary
Higher systemic inflammation response index (SIRI) levels are linked to increased mortality risk in chronic pain patients. This inflammatory biomarker may aid in stratifying mortality risk, especially in older adults.
Area of Science:
- Biomarkers
- Inflammation
- Chronic Pain Research
Background:
- Chronic pain is prevalent and associated with systemic inflammation.
- The systemic inflammation response index (SIRI) is a novel inflammatory biomarker.
- The link between SIRI and mortality in chronic pain patients is not well-established.
Purpose of the Study:
- To investigate the association between SIRI and all-cause mortality in individuals with chronic pain.
- To evaluate SIRI's utility for risk stratification in this population.
Main Methods:
- A population-based prospective cohort study using NHANES data (1999-2019).
- Cox proportional hazards regression and restricted cubic spline models analyzed SIRI and mortality.
- Multiple imputation handled missing data, with adjustments for covariates.
Main Results:
- Higher SIRI correlated with increased all-cause mortality in chronic pain patients (HR 2.56).
- The highest SIRI tertile showed a 1.45-fold higher mortality risk compared to the lowest.
- A nonlinear association was observed, with risk increasing at higher SIRI levels, particularly in adults aged ≥ 52.
Conclusions:
- Elevated SIRI is associated with higher all-cause mortality in adults with chronic pain.
- SIRI demonstrates potential as a tool for stratifying mortality risk in this demographic.
- The association was more pronounced in older adults.
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