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Externally Validated Plasma Phospholipid Panel for Pneumoconiosis Triage Across Dust-Exposed and Unexposed Worker
Junyun Wang1, Yuzhen Feng1, Junxiu Zhao2
1. NHC Key Laboratory for Engineering Control of Dust Hazard, National Center for Occupational Safety and Health, National Health Commission of the People's Republic of China, Beijing 102308, China.
Objective:
To evaluate whether targeted plasma phospholipidomics identifies an externally validated blood panel for pneumoconiosis triage across dust-exposed and nonexposed worker cohorts.
Methods:
We quantified 53 plasma phospholipids by UPLC-MS/MS in discovery (n=392) and external (n=221) cohorts comprising pneumoconiosis, dust-exposed noncase, and nonexposed healthy control participants. Candidate lipids were selected by covariate-adjusted screening and LASSO, then tested with clinical covariates.
Results:
A five-lipid panel was retained. In the external cohort, Firth logistic regression achieved AUC 0.983, sensitivity 0.923, and specificity 0.955. Cytokine-lipid correlations supported inflammatory plausibility.
Conclusions:
This panel may support occupational triage for confirmatory imaging, pending prospective multicenter validation.
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