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Updated: Aug 11, 2026

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

Role of circadian clock in oral squamous cell carcinoma pathogenesis and treatment

Mingyuan Liu1, Kai Yang1

  • 1Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Yuzhong District, Chongqing, 400016, China.

Cancer Treatment and Research Communications
|August 4, 2026
PubMed

Insights

Circadian clock disruption is linked to oral squamous cell carcinoma (OSCC) development. This review explores chronotherapy and gene-targeting strategies for OSCC prevention and treatment.

Area of Science:

  • Molecular Biology
  • Oncology
  • Chronobiology

Background:

  • The circadian clock, a molecular timing system, regulates cellular functions via clock genes.
  • Disruption of the circadian clock is implicated in various cancers, affecting homeostasis.
  • Oral squamous cell carcinoma (OSCC) is a prevalent malignancy with unclear onset mechanisms.

Purpose of the Study:

  • To review the role and mechanisms of circadian clock disruption in OSCC development and progression.
  • To summarize advances in chronotherapy and therapeutic strategies targeting circadian clock genes for OSCC.

Main Methods:

  • Literature review focusing on circadian clock genes, OSCC, and chronotherapy.
  • Analysis of molecular pathways linking circadian disruption to cancer.
  • Synthesis of current therapeutic strategies and future directions.

Main Results:

  • Circadian clock disruption contributes to OSCC initiation and advancement.
  • Chronotherapy and targeted gene therapies show promise for OSCC treatment.
  • Understanding these mechanisms offers new avenues for OSCC prevention.

Conclusions:

  • Circadian clock disruption is a significant factor in OSCC.
  • Targeting the circadian clock presents novel therapeutic opportunities for OSCC.
  • Further research is crucial for developing effective chronotherapies for OSCC.
Keywords:
Cancer therapyChronotherapyCircadian clockCircadian rhythmsOral cavityTumorigenesis

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