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Activated Cross-linked Agarose for the Rapid Development of Affinity Chromatography Resins - Antibody Capture as a Case Study
Published on: August 16, 2019
Valorisation of agro-industrial by-products: advanced extraction, purification, and computational strategies for
Thais Carvalho Brito-Oliveira1, Felipe Sanchez Bragagnolo1, Rodrigo Stein Pizani1
1Laboratório Multidisciplinar de Alimentos e Saúde (LabMAS), Faculdade de Ciências Aplicadas (FCA), Universidade Estadual de Campinas, Campinas, Limeira, Brazil.
Abstract:
Staphylococcus aureus remains a critical global threat to healthcare and food safety due to escalating antibiotic resistance. This review evaluates the valorisation of agro-industrial by-products as sustainable reservoirs of antimicrobial phenolics. It synthesises key findings on anti-S. aureus efficacy while highlighting a significant industry shift towards "green" extraction techniques, such as supercritical fluid and pressurised liquid extraction. A primary differential of this work is the comprehensive analysis of predictive computational tools-specifically Hansen Solubility Parameters and COnductor-like Screening MOdel for Real Solvents (COSMO-RS)-to rationalise solvent selection for targeted bioactive recovery. The integration of these digital strategies with advanced purification frameworks is examined for its potential to maximise antimicrobial potency and economic viability. By consolidating insights into modern processing and structure-activity relationships, this review establishes a synergistic framework for developing next-generation natural antimicrobials within a circular economy.
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