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Time Matters: BMAL1 and Cardiovascular-Kidney-Metabolic Health
Lance Dylan Reynolds1, Zhengrong Guan1, Jennifer S Pollock1
1CardioRenal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Summary
Unhealthy eating drives cardiovascular-kidney-metabolic diseases (CKMD). This review highlights how the circadian clock gene BMAL1 influences CKMD by regulating metabolism, suggesting clock-targeted therapies may offer new treatments.
Area of Science:
- Metabolic physiology
- Chronobiology
- Molecular biology
Background:
- Modern lifestyles promote unhealthy eating, increasing cardiovascular-kidney-metabolic diseases (CKMD).
- Circadian rhythms, regulated by clock genes like BMAL1, are vital for metabolic homeostasis and interact with feeding behaviors.
- BMAL1 is a key transcription factor coordinating metabolic functions within the circadian regulatory loop.
Purpose of the Study:
- To review the role of BMAL1 in metabolic physiology and its impact on CKMD.
- To explore how BMAL1 influences CKMD outcomes based on diet, feeding schedules, and sex.
- To discuss the therapeutic potential of targeting molecular clock pathways for CKMD.
Main Methods:
- Analysis of global and tissue-specific Bmal1 knockout animal models.
- Review of recent literature on circadian biology, feeding behavior, and metabolic physiology.
- Examination of BMAL1's role in response to varying dietary compositions and feeding schedules.
Main Results:
- BMAL1 plays a critical role in coordinating metabolic processes influenced by feeding behavior.
- BMAL1's function is integral to metabolic homeostasis and influences CKMD development.
- Sex and environmental factors like diet and feeding times modulate BMAL1's impact on CKMD.
Conclusions:
- Maintaining circadian rhythm integrity is crucial for mitigating CKMD.
- BMAL1 is a key molecular link between circadian rhythms, feeding behavior, and metabolic health.
- Targeting BMAL1 and clock-regulated pathways presents a promising therapeutic strategy for CKMD.
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