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Experimental Infection of Mice with the Parasitic Nematode Strongyloides ratti
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Published on: January 17, 2025

A case of severe strongyloidiasis complicating immunosuppressive therapy initiated for IgA vasculitis

Limei Hu1, Yihe Chen2, Ying Liang1

  • 1Department of Laboratory Medicine, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

Parasites, Hosts and Diseases
|August 5, 2026
PubMed

IgA vasculitis (IgAV) and Strongyloides stercoralis infection may both present with abdominal pain and purpura; however, glucocorticoid, the treatment for IgAV, is a major risk factor for S. stercoralis hyperinfection syndrome and disseminated strongyloidiasis. To date, only 2 cases of IgAV with concurrent S. stercoralis infection have been reported globally, both in children. We report a 72-year-old man presenting with abdominal pain and purpura. Diagnosed with IgAV during this admission, he received glucocorticoid therapy. However, the patient's condition did not improve as expected. Subsequently, S. stercoralis was detected in the patient's sputum and stool. We report the first adult case of IgAV with concurrent S. stercoralis infection, highlighting the importance of screening patients with IgAV for strongyloidiasis before initiating immunosuppressive therapy.

Keywords:
IgA vasculitisStrongyloides stercoralisimmunosuppressive therapysevere strongyloidiasis

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