An open-source framework for image-based planning and PET/computed tomography dosimetry in yttrium-90...

Area of Science:

• Medical Physics
• Radiology
• Oncology

Background:

• Yttrium-90 (Y-90) radioembolization requires precise dosimetry for effective treatment.
• Current dosimetry methods can be complex and rely on proprietary software.

Purpose of the Study:

• To introduce Yttrium Radioembolization Dosimetry Evaluation (YRDose), an open-source software suite.
• To provide a platform for image-based activity planning and post-therapy dosimetry in Y-90 radioembolization.

Main Methods:

• YRDose was developed using Python within the 3D Slicer platform.
• It integrates CT and technetium-99m SPECT/CT for pre-therapy planning and optional Y-90 PET/CT for verification.
• The workflow includes segmentation, LSF calculation, activity allocation, and dose estimation.

Main Results:

• The YRDose framework enables sequential image analysis, volumetric LSF calculation, and absorbed dose estimation.
• It preserves traceability and reproducibility by storing all data within a single scene.
• The software facilitates personalized dosimetry workflows in research settings.

Conclusions:

• YRDose offers a reproducible, open-source platform for Y-90 radioembolization planning and dosimetry.
• It serves as an accessible research framework for institutions lacking proprietary solutions.
• Further validation is required for routine clinical use.