Biosensor applications in organ-on-a-chip platforms and disease modeling

Area of Science:

• Biomedical Engineering
• Cellular Biology
• Pharmacology

Background:

• Microphysiological systems (MPS) and organ-on-a-chip (OoC) systems are crucial for in vitro cell and tissue modeling.
• Understanding dynamic cellular microenvironments and disease mechanisms requires advanced modeling techniques.

Purpose of the Study:

• To review biosensor types and advancements for in vitro modeling.
• To highlight organ-on-a-chip systems integrated with biosensors for disease modeling applications.

Main Methods:

• Review of current literature on biosensor technology and OoC systems.
• Focus on the integration of biosensors within OoC platforms.
• Examination of specific applications in disease modeling.

Main Results:

• OoC systems with biosensors enable accurate modeling of human physiology and disease.
• These platforms offer non-invasive, real-time monitoring of cellular behaviors and responses.
• Biosensor integration allows precise detection of biomarkers and drug effects.

Conclusions:

• Integrated OoC-biosensor platforms provide physiologically relevant models for drug screening and personalized medicine.
• These systems offer valuable insights into disease mechanisms, drug toxicity, and therapeutic efficacy.
• Advancements in biosensor technology enhance the capabilities of in vitro modeling.