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Updated: Aug 6, 2026
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Fabrication and Characterization of Microneedle Patches for Loading and Delivery of Exosomes
Published on: July 12, 2024
Microneedle-Assisted Cell Delivery and Therapy
Ruochen Qiao1,2, Dasheng Li3, Long Wang1
1State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University, Nanjing University, Nanjing 210093, China.
Research (Washington, D.C.)
|August 5, 2026
Summary
Microneedle (MN) systems offer innovative solutions for cell delivery, overcoming challenges in regenerative medicine. This review explores MN advancements for various organ applications and discusses barriers to clinical translation.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Nanotechnology
Background:
- Cell-based therapeutics show promise but face delivery challenges like kinetics, safety, and adherence.
- Microneedle (MN) technology presents a novel approach to enhance cell delivery for therapeutic applications.
Purpose of the Study:
- To provide a comprehensive review of microneedle-based cell delivery systems.
- To analyze MN innovations, applications across organs, and translational barriers.
Main Methods:
- Literature review of recent innovations in microneedle technology for cell delivery.
- Classification of MN systems based on material, fabrication, and function.
- Analysis of MN applications in skin, endometrium, cardiac, and oral disorders.
Main Results:
- Microneedle systems are advancing cell delivery for regenerative medicine, including stem and immune cells.
- Diverse MN designs and materials offer unique advantages for specific organ targets.
- Key translational barriers include manufacturing, storage stability, and regulatory hurdles.
Conclusions:
- Microneedle technology is a promising platform for improving cell-based therapeutics.
- Addressing manufacturing, stability, and regulatory issues is crucial for clinical translation.
- This review offers a systematic overview to guide future MN-based cell delivery system design.
