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Synchronous Multiple Primary Tumors in a Dog: A Case Report
Mohammad Reza Foroughi-Gilvaee1, Nadi Maazi2, Negin Raazi3
1Department of Health Education and Promotion, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran, tums.ac.ir.
Case Reports in Veterinary Medicine
|August 5, 2026
Summary
Diagnosing multiple primary tumors (MPTs) in dogs is complex. This case used multimodal diagnostics to differentiate MPTs from metastasis in a geriatric canine patient, guiding successful treatment.
Area of Science:
- Veterinary Oncology
- Canine Pathology
Background:
- Multiple primary tumors (MPTs) present diagnostic challenges in veterinary medicine, especially when distinct lesions are present.
- Geriatric canine patients with concurrent masses require careful evaluation to differentiate primary tumors from metastatic disease.
Purpose of the Study:
- To describe a case of multiple primary tumors in a geriatric dog.
- To highlight the importance of multimodal diagnostics in differentiating MPTs from metastasis.
- To outline a therapeutic approach for complex canine oncology cases.
Main Methods:
- Clinical presentation of a 9-year-old female dog with mammary and cutaneous masses.
- Diagnostic imaging (including thoracic radiographs) to assess for metastasis.
- Histopathological and immunohistochemical analysis of excised masses (mammary carcinoma, melanosis, acrochordons).
- Multimodal treatment including surgery and chemotherapy.
Main Results:
- Histopathology confirmed a low-grade mammary carcinoma, a melanocytic lesion with borderline proliferative features in a lymph node, and benign acrochordons.
- No evidence of pulmonary metastasis was found on imaging.
- The dog tolerated treatment, with no recurrence or metastasis noted within six months post-therapy.
- Post-treatment bloodwork indicated mild cytopenias and hepatocellular stress.
Conclusions:
- Multimodal diagnostic approaches are crucial for accurate diagnosis of MPTs in dogs.
- Distinguishing MPTs from metastasis is essential for appropriate therapeutic planning in complex geriatric oncology.
- This case demonstrates successful management of concurrent neoplastic and non-neoplastic lesions in an older canine patient.
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