A Universal Multifunctional Zinc Ionic Semi-Interpenetrating Network Hydrogel Coating on Polymer Surfaces

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Surface Engineering

Background:

• Medical device coatings aim to reduce tissue damage and improve integration.
• Challenges exist in achieving strong bonding and multiple functionalities in hydrogel coatings.

Purpose of the Study:

• To develop a universal, multifunctional zinc ionic semi-interpenetrating network hydrogel coating (Zn-SIHC) for medical devices.
• To enhance interfacial bonding, mechanical strength, and biocompatibility for tissue-friendly interventions.

Main Methods:

• Surface-initiated polymerization of acrylamide to form a covalent network.
• Incorporation of chitosan and cross-linking with zinc ions to form an ionic network.
• In situ generation of the Zn-SIHC coating on polymer surfaces.

Main Results:

• Zn-SIHC exhibited a fourfold increase in tensile strength and high peeling strength (~900 N/m).
• The coating demonstrated excellent lubricity (CoF = 0.05), transparency (91%), antifouling properties, and antibacterial capability.
• In vivo studies in monkeys showed Zn-SIHC alleviated intubation-related side effects, reducing inflammation and apoptosis.

Conclusions:

• Zn-SIHC offers a promising solution for robust, multifunctional hydrogel coatings on medical devices.
• The developed coating enhances biocompatibility and mitigates tissue injury, paving the way for improved medical interventions.
• This work presents a novel approach to surface engineering for medical devices using ionic hydrogel networks.