Related Experiment Video
Updated: Aug 6, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
A Comparison of Latent and Deterministic Blockmodeling with Application to Binary Substance Use Disorder Data
Michael Brusco1, Douglas Steinley2, Ashley L Watts3
1Department of Business Analytics, Information Systems, and Supply Chain, Florida State University, Tallahassee, FL, USA.
Abstract:
Substance use disorder data are often collected by asking individuals to endorse (or not endorse) a set of items pertaining to various diagnostic criteria. The result is a bipartite network, which can be represented by a two-mode binary matrix with rows corresponding to the individuals and columns to the items. Two-mode blockmodeling is an exploratory data analysis approach for bipartite networks that establishes partitions of both the individuals and items. Some two-mode blockmodeling methods are deterministic, whereas the latent blockmodel is stochastic and grounded by an underlying statistical model. A simulation study comparing the latent blockmodel and two deterministic blockmodeling methods revealed that the methods often perform comparably with respect to recovery of the true (known) cluster memberships when the number of clusters for both individuals and items is prespecified. However, the results also showed that one of the deterministic methods is unsuitable for sparse bipartite networks. A key advantage of the latent blockmodel method is a principled approach to selection of the number of clusters for individuals and items. We also demonstrate the effectiveness of the latent blockmodel via comparison to deterministic blockmodeling for a multiple-substance use disorder data set from the literature.
More Related Videos
07:31Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
Published on: January 7, 2019
06:52Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills
Published on: September 17, 2019
Related Concept Videos
Mechanistic Models: Compartment Models in Individual and Population Analysis
Mechanistic Models: Overview of Compartment Models
Pharmacodynamic Models: Link Model and Systems Pharmacodynamic Model
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
Pharmacodynamic Models: Additive and Proportional Drug Effect Model
Model Approaches for Pharmacokinetic Data: Compartment Models
Two primary types of compartment models are recognized: mammillary and catenary. The more...