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Associations Between the Inflammation Burden Index and Cardiovascular-Kidney-Metabolic Syndrome: A Cross-Sectional
Yixuan Wu1, Mei Li1, Zhen Fang1,2
1College of Materials and Food, University of Electronic Science and Technology Zhongshan Institute, Zhongshan, China.
Metabolic Syndrome and Related Disorders
|August 5, 2026
Summary
Elevated inflammation burden index (IBI) is linked to increased risk of advanced cardiovascular-kidney-metabolic (CKM) syndrome. This finding suggests IBI can help identify high-risk individuals for CKM syndrome.
Area of Science:
- Cardiovascular research
- Nephrology
- Metabolic disease research
Background:
- Cardiovascular-kidney-metabolic (CKM) syndrome involves interconnected cardiovascular, kidney, and metabolic dysregulation.
- Systemic inflammation is a key contributor to CKM syndrome development and progression.
Purpose of the Study:
- To investigate the association between the inflammation burden index (IBI) and the risk of advanced CKM syndrome (stages 3-4).
- To analyze data from the National Health and Nutrition Examination Survey (NHANES) for this association.
Main Methods:
- Utilized data from six NHANES cycles (1999-2010) encompassing 13,830 participants.
- Employed weighted multivariable logistic regression and restricted cubic splines to assess IBI's association with CKM stages 3-4.
- Conducted subgroup and sensitivity analyses to confirm the robustness of findings.
Main Results:
- A positive association was found between elevated IBI and increased risk of CKM stages 3-4 (OR = 1.026, P = 0.005).
- This association remained significant even after excluding patients with hypertension and diabetes.
- A nonlinear dose-response relationship between IBI and CKM risk was identified.
Conclusions:
- The inflammation burden index (IBI) is independently associated with a higher risk of advanced CKM syndrome.
- IBI, as a composite inflammatory marker, shows potential for identifying individuals at high risk for CKM syndrome.
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