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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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The Impact of Donor RBC Storage Duration on the Efficacy of Chronic RBC Exchange

Jaehyup Kim1

  • 1Department of Pathology, Division of Transfusion Medicine and Hemostasis, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Journal of Clinical Apheresis
|August 5, 2026
PubMed
Summary

Freshness-waived red blood cells (RBCs) in chronic RBC exchange (RBCx) reduced RBC lifespan but did not significantly impact hematocrit or HbS levels. Relaxing RBC freshness criteria may lower costs without affecting outcomes.

Keywords:
RBC exchangehemoglobinopathysickle cell diseasetransfusion

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