Association Between Psoriasis and Overactive Bladder Among US Adults: A Study Based on 2005-2006 and 2009-2014...

Both psoriasis and overactive bladder (OAB) are considered systemic conditions that share many inflammatory or immune pathways in the pathogenesis. One previous study found patients with psoriatic arthritis (PsA) reported significantly higher bladder autonomic dysfunction scores compared to controls. But it is currently unclear whether there is an association between psoriasis and OAB.

To assess the association between psoriasis and OAB among US population.

This cross-sectional, population-based study utilized representative data of US adults aged 20 -59 years from the National Health and Nutrition Examination Survey (NHANES) 2005-2006 and 2009-2014 cycles. The Overactive Bladder Symptom Score (OABSS) was used to define OAB and group its severity into none, mild, moderate, and severe. Weighted logistic regression models were constructed to investigate the association between psoriasis with OAB or OAB severity. Subgroup analyses were performed to identify whether certain factors could influence the relationship. Sensitivity analyses were further conducted to assess the robustness of our findings.

Among 11,643 participants, 50.95% were male and the mean age at recruitment was 39.67 (11.55) years. The prevalence of psoriasis increased with OAB severity (2.34% [none], 3.01% [mild], 5.13% [moderate], 5.33% [severe]; p = 0.0008). In weighted logistic regression models, psoriasis was significantly associated with OAB (OR = 1.88, 95% CI: 1.32-2.68) after adjusting all covariates, as well as the severity of OAB. Subgroup analyses indicated that the association was stronger among younger participants, males, participants with obesity or hypertension, and those without diabetes or cardiovascular disease (CVD); conversely, no significant associations were observed in participants with pre-diabetes, diabetic mellitus, or CVD. Sensitivity analyses confirmed the robustness of these findings.

This study demonstrates a significant association between psoriasis and OAB, with a positive correlation to OAB severity, underscoring the need for early identification and management of OAB symptoms in psoriasis patients to improve overall patient outcomes and enhance their quality of life.