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Development of SCOPE: Social and Clinical Opioid Use Disorder Predisposition Evaluation
Journal of Addiction Medicine
|August 5, 2026
Summary
Researchers identified social determinants of health (SDoH) and clinical factors for opioid use disorder (OUD). They developed the SCOPE tool to help clinicians assess OUD risk at the bedside.
Area of Science:
- Public Health
- Clinical Informatics
- Addiction Medicine
Background:
- Opioid use disorder (OUD) poses a significant public health challenge.
- Identifying individuals at high risk for OUD is crucial for timely intervention.
- Social determinants of health (SDoH) play a vital role in health outcomes, including OUD.
Purpose of the Study:
- To identify SDoH, demographic, and clinical predictors of OUD.
- To develop a clinical risk-stratification tool for OUD, named SCOPE.
- To enable bedside risk assessment for OUD by clinicians.
Main Methods:
- Utilized participant data from the All of Us Research Program.
- Employed multivariable logistic regression to identify OUD predictors.
- Constructed the SCOPE calculator using odds ratios and validated its performance (AUROC, sensitivity, specificity).
Main Results:
- Analyzed data from 624,431 participants, with 0.39% diagnosed with OUD.
- The SCOPE tool demonstrated an average AUROC of 0.85.
- A cutoff score of 8 indicated high risk, with a sensitivity of 0.79 and specificity of 0.76.
Conclusions:
- Individual and SDoH-related factors are associated with OUD risk.
- The developed SCOPE tool can aid clinicians in personalized OUD risk identification.
- SCOPE serves as a clinical decision-making aid for bedside OUD risk stratification.
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