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Who Is the Ideal Candidate for High-Definition Liposuction? A Systematic Review and Meta-Analysis
Ryan Guidi1, John A Toms2, Stephanie Taiberg3
1Rush Medical College of Rush University, Chicago, IL.
Annals of Plastic Surgery
|August 5, 2026
Summary
High-definition liposuction (HDL) is safe and effective for enhancing muscular definition. This review found low complication rates across diverse patient groups, though ideal candidate criteria require further study.
Area of Science:
- Plastic Surgery
- Cosmetic Surgery
- Body Contouring
Background:
- High-definition liposuction (HDL) improves muscular definition by removing superficial subcutaneous fat.
- Despite popularity and high patient satisfaction, ideal candidate criteria for HDL remain undefined.
- This review assesses demographic factors, selection criteria, and complications of HDL.
Purpose of the Study:
- To systematically review and evaluate demographic factors, patient selection criteria, and complication rates associated with high-definition liposuction.
- To synthesize current evidence on the safety and efficacy of HDL procedures.
Main Methods:
- Systematic review and meta-analysis following PRISMA-P guidelines.
- Searched PubMed, Cochrane Library, Embase, and Web of Science for studies within the last 10 years.
- Included 17 studies (9570 patients) with RCTs, cohort, and observational designs; performed pooled analyses for seroma and hematoma.
Main Results:
- Mean patient age was 36.0 years, mean BMI 25.8 kg/m², and 55% were female.
- Commonly treated areas included the abdomen, flanks, and chest; mean fat removal was 4268.8 mL.
- Low complication rates observed: seroma (7%), hematoma (1%); no significant association found between complications and age, BMI, or sex.
Conclusions:
- High-definition liposuction is a safe and effective procedure across varied populations.
- Variability in selection criteria and reporting hinders the definition of ideal HDL candidates.
- Further prospective studies with standardized reporting are necessary to establish evidence-based guidelines for ideal patient selection.