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Overcoming Transmission Barriers: A Dual-Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and
Ming Zhang1, Jiaxin Tian2,3, Xiaolong Zhu2
1State Key Laboratory Cultivation Base of Research, The Affiliated Stomatological Hospital of Nanjing Medical University, Prevention and Treatment for Oral Diseases, Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing, China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|August 5, 2026
Summary
This study introduces a novel hydrogel for monkeypox virus (MPXV) treatment, effectively clearing the virus, reducing inflammation, and promoting tissue repair for improved clinical outcomes.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Infectious Disease Research
Background:
- Monkeypox virus (MPXV) infection presents significant clinical challenges due to local inflammation and persistent viral replication.
- Current treatments struggle to simultaneously achieve viral clearance and effective tissue repair.
Purpose of the Study:
- To develop an innovative functionalized hydrogel for treating MPXV infection.
- To integrate photothermal performance, anti-inflammatory properties, and enhanced biointerfacial characteristics into a single therapeutic material.
Main Methods:
- A hierarchical assembly strategy involving "mesoporous carrier anchoring-gel matrix embedding" was employed.
- Mesoporous polydopamine (mPDA) served as an anchoring site for a polymer, creating a photothermal component.
- This component was embedded within a biocompatible gel matrix to form the Polymer@mPDA@Gel hydrogel.
Main Results:
- The developed hydrogel demonstrated precise integration of photothermal, anti-inflammatory, and biointerfacial properties.
- The functionalized hydrogel successfully achieved targeted MPXV clearance.
- The material facilitated inflammation regulation and supported tissue repair processes.
Conclusions:
- The novel functionalized hydrogel offers a promising new material technology for MPXV infection treatment.
- This approach provides a new theoretical basis for addressing viral infections with integrated therapeutic functions.
