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Differential Tissue-Coupled Powering for Battery-Free Injectable Electroceuticals
Han Wu1, Sultan Mahmud1, Mali Halac2
1Department of Electrical and Computer Engineering, University of Florida, Gainesville, USA.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|August 5, 2026
Summary
Researchers developed a Thread-like Injectable Neural TechnologY (TINY) using differential tissue-coupled powering (DTCP) for wireless energy transfer. This innovation enables effective, injectable neurostimulation for neurological disorders.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Implantable Devices
Background:
- Injectable electroceutical implants offer therapeutic potential for neurological and peripheral disorders.
- Wireless powering of ultra-miniaturized, fully injectable systems presents a significant technological hurdle.
Purpose of the Study:
- To introduce a novel powering strategy for injectable electroceuticals.
- To demonstrate the feasibility of wireless power transfer for neural stimulation using a thread-like implant.
Main Methods:
- Development of a Thread-like Injectable Neural TechnologY (TINY) utilizing differential tissue-coupled powering (DTCP).
- Characterization of power-transfer efficiency (PTE) using tissue-mimicking phantoms and in vivo rat models.
- Assessment of device positioning and local tissue response over 20 days.
Main Results:
- DTCP enables power harvesting scalable with implant length, overcoming miniaturization limitations.
- Benchtop and in vivo studies confirmed effective wireless power transfer and sciatic nerve activation at centimeter depths.
- The system demonstrated high tolerance to angular misalignment.
Conclusions:
- Differential tissue-coupled powering (DTCP) is a scalable and alignment-robust strategy for wirelessly powering injectable electroceuticals.
- This technology addresses critical challenges in minimally invasive neuromodulation therapies.
