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An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing
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A Microcapsule-Integrated smRandom-seq Platform Enables Fixation-Free Single Microbe RNA Sequencing

Mengdi Song1, Yuting Wang1, Zhaolun Wang2

  • 1Department of Laboratory Medicine of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|August 5, 2026
PubMed
Summary

No abstract available in PubMed .

Keywords:
aqueous two‐phase systemfixation‐free workflowmicrocapsulesingle‐microbe RNA sequencing

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RNA-seq03:21

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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
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Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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